Year in Review 2014: Aerosol Delivery Devices.

Review: various devices for delivery of aerosol treatment can be equally efficacious.

Aerosol delivery devices in the treatment of asthma.

Nebulizers convert solutions or suspensions into aerosols with a particle size that can be inhaled into the lower respiratory tract. There are pneumatic jet nebulizers, ultrasonic nebulizers, and mesh nebulizers. Newer nebulizer designs are breath-enhanced, breath-actuated, or have aerosol-storage bags to minimize aerosol loss during exhalation. Nebulizers can be used with helium-oxygen mixture...

Inhalation drug delivery devices: technology update

The pulmonary route of administration has proven to be effective in local and systemic delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non-pulmonary diseases. A successful pulmonary administration requires a harmonic interaction between the drug formulation, the inhaler device, and the patient. However, the biggest single problem that accounts for the lack of desir...

Aerosol administration during nasal CPAP in newborns can be optimized.

Aerosols have proven to be an effective form of drug delivery. Nevertheless, the development of devices as well as medical agents for aerosolization to treat mechanically ventilated newborns still presents a substantial challenge.1 Low tidal volumes and functional residual capacity, high breathing frequency, short aerosol particle residence time, and small airway diameters cause low aerosol dep...

Improving aerosol drug delivery during invasive mechanical ventilation with redesigned components.

INTRODUCTION Patients receiving invasive mechanical ventilation with an endotracheal tube (ETT) can often benefit from pharmaceutical aerosols; however, drug delivery through the ventilator circuit is known to be very inefficient. The objective of this study was to improve the delivery of aerosol through an invasive mechanical ventilation system by redesigning circuit components using a streaml...